A: Hi romanni,

Not directly, no. The plugin is made to work with WordPress. You can potentially use the CDN as well as the local Compress API depending on your PHP proficiency. As Shane has stated previously:
"You can use the Easy IO CDN anywhere that you would use any "normal" CDN like Cloudfront, KeyCDN, etc. By default it will do premium image compression and WebP conversion, but you can take advantage of the CDN API for image scaling/cropping and that sort of thing: https://docs.ewww.io/article/115-exactdn-easy-io-api"