Pretty easy to configure, albeit to get it setup right you'll need to understand a little about email and adding records to your domain. Limited, but nice features - including automatically generating addresses when wildcard is used to capture new, inbound addresses.

Properly secures whatever address you are using 'behind' your vanity/personal domain although it IS possible to leak a personal address by sending from the wrong outbound address (currently this relay is allowed, though I've suggested to Alex this should be blocked - would assist in avoiding spam also).

Lots of API/programmer support - including building your own bots to deal with inbound email, but I have not tested this (additional costs apply, as they should do).